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Overview of the Extrusion-Spheronization Process

Extrusion Spheronization

The extrusion-spheronization process is comonnly used in the pharmaceutical industry to make uniformly sized spheroids. It is especially useful for making dense granules for controlled-release solid dosage oral forms with a minimum amount of excipients.

Extrusion is a necessary first step in the extrusion-spheronization process. The size of the extruder aperture will dictate the approximate size of the resulting spheriods.


The extrusion-spheronization process can be broken down into the following steps:


Chart showing the extrusion spheronization steps.


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