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Rheometry

Definition of Rheometer:

Rheo flow properties of a material. Meter measure and quantify.

Introduction to the Caleva Mixer Torque Rheometer

The Caleva Mixer Torque Rheometer

The Caleva Mixer
Torque Rheometer

The Caleva Mixer Torque Rheometer is a useful research and quality control tool.

The Mixer Torque Rheometer (MTR) is used for investigation of the properties of wet masses and the study of binder substrate interactions.

MTR offers a means to scientifically explain, predict, screen and characterize WET MASSING processes/materials used in the following stages for the development and production of Pharmaceutical Solid Dosage Forms:

Requirements:

 

The Caleva MTR: What can it do for you?

Research

Formulation Development

Process Control

Basic Configuration of the MTR

MTR Blades and Bowl

MTR Blades and Bowl

The MTR is basically an instrumented, small capacity, twin blade, high shear shear mixer. The torque from the rotating blades exerts a force on a load cell by the reaction of the bowl to the turning blades. An attached personal computer running the Windows based MTR software records the force imparted on the load cell.

 

 

 

 

 

The MTR for Research:

1. Basic investigation of the wet granulation and extrusion/spheronization processes

Graph of Torque vs. Binder

Torque vs. Binder

Investigation of binder-substrate interactions

Graph showing differences in torque curve as result of different binders

Different Torque Curve
for Different Binders

 

The MTR for Formulation Devlopment

To check source and/or batch variations in excipients

Graph showing differences in torque curve on an excipient from 3 different sources

Different Torque Curve
for MCC from Three
Different Sources

 

 

 

 

 

Source variation in constituents of a formulation

Graph showing differences in torque curve on an excipient from 2 different sources

Different Torque Curve
for MCC from Two
Different Sources

 

 

 

To Quantify The Suitability of Different Binder Concentrations

Graph showing differences in torque curves due to different binder concentrations

Different Torque Curves
for Different
Binder Concentrations

 

 

 

Mixing Time

Graph showing effects of different mixing time on torque

Effects of
Different Mixing Time

 

 

 

Process Control

Monitoring Production Scale Granulation for Process Control

Graph showing different consistency for different excipient samples

Different Consistiencies
for Different
Excipient Samples

 

 

 

 

8.


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